The Enigmatic Cytokine Oncostatin M and Roles in Disease

Figure 1

Schematic diagram of the gp130 cytokine receptor complexes. Members of the gp130 cytokine family engage in receptor complexes that include the gp130 signal transduction chain with the exception of IL-31, which engages a complex that utilizes gp130-like (GPL or IL31α) chain. The family may be subdivided further according to the signaling chains utilized: gp130/gp130; gp130/LIFR; gp130/OSMRβ; GPL/OSMRβ, and gp130/WSX-1, (modified from Fritz [39]).