The Enigmatic Cytokine Oncostatin M and Roles in Disease

Figure 2

OSM receptors and signaling. A schematic representation of signal transduction initiated through the OSMR/gp130 receptor complex. While several gp130-utilizing cytokines activate JAK/STAT and MAPK signaling pathways in connective tissue cells, we observe that OSM uniquely activates additional signaling intermediates including STAT5, STAT6, the PI3′K/Akt pathway, and the novel PKC isoform PKC delta (PKCd) in fibroblasts. OSM induces IL-4Ralpha and IL-1R (modified from Fritz [39]).