Research Article

Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography

Table 2

Accuracy results of 2-CMPB and 2-BMPB.

S. no2-CMPB2-BMPB
LOQ level50% level100% level150% levelLOQ level

Added* (µg/g)0.952.474.967.432.84
Found* (µg/g)0.922.575.297.542.82
Recovery (%)96.8104.0106.7101.599.3
% RSD*2.72.00.31.13.4

Average recovery**102.3

Average of 3 replicates.
**Average recovery of four levels.