Review Article
Adjuvant Treatment of Melanoma
Table 10
Most common adverse events (degree III/IV) in patients treated with high dose IFN-α2b.
| | Patients (%)* | Patients (%)* |
| Adverse effects | All degrees | Degree 3-4 | Asthenia | 96 | 21–24 | Fever | 81 | 18 | Myalgia | 754 | 4–17 | Nauseas | 66 | 5–9 | Vomiting | 66 | 5 | Myelosuppression | 92 | 26–60 | Elevated AST | 63 | 14–29 | Neuropsychiatric symptoms | 40 | 2–10 | (i) Depression | | (ii) Anxiety | 0–70% | (iii) Suicidal thoughts | |
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taken from the E1684 study of 143 patients. taken from the E1684, E1690, and E1694 studies.
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