Review Article

Adjuvant Treatment of Melanoma

Table 10

Most common adverse events (degree III/IV) in patients treated with high dose IFN-α2b.

Patients (%)*Patients (%)*

Adverse effectsAll degreesDegree 3-4
Asthenia9621–24
Fever8118
Myalgia7544–17
Nauseas665–9
Vomiting665
Myelosuppression9226–60
Elevated AST6314–29
Neuropsychiatric symptoms402–10
 (i) Depression
 (ii) Anxiety0–70%
 (iii) Suicidal thoughts

taken from the E1684 study of 143 patients. taken from the E1684, E1690, and E1694 studies.