Review Article
Adjuvant Treatment of Melanoma
Table 11
Arguments for and against high dose interferon as adjuvant treatment.
| (1) Arguments in favour: | (i) A consistent improvement in disease-free survival has been demonstrated in all studies carried out | (ii) An improvement in global survival has been shown, but without this being statistically significant | (iii) The toxicity is high, but manageable by experienced medical teams | (iv) No other therapeutic regime has shown benefits in the adjuvance of melanoma |
| (2) Arguments against: | (i) It is not clear which population most benefits from the adjuvant treatment | (ii) The benefit is only clear for disease-free survival, with no consistent information referring to global survival | (iii) The toxicity is considerable | (iv) The ideal duration and dose for the treatment are unknown |
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