Review Article

Adjuvant Treatment of Melanoma

Table 12

High risk melanomas: adjuvant treatment with low and intermediate dose interferon.

Trial No. of casesSLEOS

Low dose IFN (3 mU × 3/s × 3 y.):
 WHO-16 (Cascinelli et al.2001) [47]426NSNS
 UK [48]674NSNS
 Scottish study (2001) [49]**59NSNS
Ultralow dose IFN (1 mU):
 EORTC/DKG-80 (Eggermont. 2001) [50]830NSNS
Low dose INF + Isotretinoin (IFN: 3 mU × 3/s × 2 y.)
 ECAMTSG ([51])407NSNS
Intermediate dose IFN.
 EORTC 18952*  1388NSNS
 (10 mill. 13 m versus 5 mill. 25 m. versus observation)

Eggermont et al. Semin. Oncol. Spanish Ed. 3, 221–227, 2003*.
Hancock et al. J. Clin. Oncol. 22, 53–61, 2004 [48].
Cameron et al. BJC. 84(9): 1146–1149, 2001**
Richtig et al. JCO. 23, 34, 2005 [51].