Review Article
The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells
Table 2
Changes in surface marker expression throughout the mouse primitive erythroid lifespan.
| | Surface protein | Early EryP-CFC
(E7.5) | EryP-CFC
(E8.5) | Early circulating EryP (E9.0-11.5) | Late circulating EryP
(E11.5>) | Fetal liver EryP | Primitive retics. |
| | Flk1 | ++ | — | — | — | ND | — | | CD144/VE-cadherin | ++ | — | — | — | ND | — | | Tie2 | +++ | ++++ | — | — | ND | ND | | Endoglin | +++ | ++++ | — | — | — | — | | CD31/PECAM | ++++ | ++++ | — | — | ND | — | | CD41 | ++++ | ++++ | — | — | — | — | | c-Kit | +++ | ++++ | — | — | — | — | | CD71 | ND | ND | ++++ | +++ | +++ | + | | Ter-119 | — | — | ++ | ++++ | ++++ | +++ | | CD9 | ND | ND | ++++ | ++++ | ++++ | — | | CD24 | ND | ND | ++++ | ++++ | ND | ND | | CD55 | ND | ND | ++++ | ++++ | ND | ND | | CD147/Basigin | ND | ND | ++++ | ++++ | ND | ++++ | | a4 integrin | ++++ | ++++ | — | + | ++++ | — | | a5 integrin | ++++ | ++++ | — | + | ++++ | — | | b1 integrin | ++++ | ++++ | — | + | ++++ | — | | CD44 | ++++ | ++++ | — | + | ++++ | — | | CXCR7 | ND | ND | — | +++ | ND | ND |
|
|
Indicate relative levels of surface expression. References included in main body of text.
|
