Research Article

Synergistic Effects of Nonthermal Plasma and Disinfecting Agents against Dental Biofilms In Vitro

Table 2

Linear regression models evaluating effects of different agents and plasma procedures on lg (CFU/mL + 1) for S. mutans, saliva, and subgingival biofilms (first agent then plasma).

S. mutans ( , Saliva ( , )Subgingival ( , )
B (95% CI)P B (95% CI)P B (95% CI)P

Agent (ref. NaCl control)
 CHX−1.78 (−2.06; −1.50)<0.001−0.29 (−0.59; 0.02)<0.001−0.74 (−1.12; −0.36)<0.001
 OCT−1.84 (−2.12; −1.56)<0.001−0.79 (−1.10; −0.49)<0.001−1.54 (−1.91; −1.16)<0.001
 PHMB−2.51 (−2.81; −2.22)<0.001−0.87 (−1.22; −0.53)<0.001−0.96 (−1.34; −0.58)<0.001
 NaOCl−6.91 (−7.20; −6.61)<0.001−2.39 (−2.89; −1.90)<0.001−1.76 (−2.14; −1.38)<0.001
 H2O2−6.91 (−7.19; −6.63)<0.001−1.50 (−1.94; −1.06)<0.001−1.89 (−2.27; −1.51)<0.001
 EDTA−1.11 (−1.38; −0.84)<0.001−0.64 (−1.08; −0.19)0.005−1.74 (−2.12; −1.36)<0.001

Procedure (ref. control)
 Ar gas−0.35 (−0.63; −0.07)0.02−0.42 (−0.76; −0.07)0.02−1.34 (−1.64; −1.04)<0.001
 Ar plasma−2.10 (−2.34; −1.87)<0.001−1.49 (−1.76; −1.22)<0.001−2.16 (−2.46; −1.86)<0.001

Interaction agent × procedure
 CHX × Ar gas0.18 (−0.25; 0.60)0.42−0.68 (−1.17; −0.19)0.0080.24 (−0.31; 0.79)0.40
 OCT × Ar gas0.29 (−0.14; 0.71)0.19−0.58 (−1.10; −0.61)0.030.22 (−0.33; 0.78)0.43
 PHMB × Ar gas−0.53 (−0.99; −0.07)0.020.15 (−0.44; 0.75)0.610.44 (−0.12; 0.99)0.12
 NaOCl × Ar gas0.35 (−0.10; 0.79)0.12−0.07 (−0.78; 0.64)0.841.35 (0.80; 1.91)<0.001
 H2O2 × Ar gas0.35 (−0.09; 0.78)0.120.08 (−0.59; 0.75)0.811.38 (0.83; 1.94)<0.001
 EDTA × Ar gas0.19 (−0.22; 0.61)0.360.32 (−0.33; 0.98)0.331.05 (0.50; 1.61)<0.001
 CHX × Ar plasma1.93 (1.53; 2.33)<0.0010.08 (−0.34; 0.50)0.720.91 (0.35; 1.46)0.001
 OCT × Ar plasma2.09 (1.70; 2.49)<0.001−0.51 (−0.92; −0.10)0.021.70 (1.15; 2.25)<0.001
 PHMB × Ar plasma1.26 (0.85; 1.68)<0.0010.80 (0.35; 1.25)0.0011.04 (0.49; 1.60)<0.001
 NaOCl × Ar plasma2.10 (1.70; 2.51)<0.0010.81 (0.16; 1.47)0.022.27 (1.72; 2.82)<0.001
 H2O2 × Ar plasma2.10 (1.70; 2.50)<0.0010.57 (−0.05; 1.19)0.071.12 (0.57; 1.67)<0.001
 EDTA × Ar plasma0.44 (0.04; 0.84)0.03−0.69 (−1.31; −0.08)0.031.82 (1.26; 2.37)<0.001

Ar: argon; CHX: 0.1% chlorhexidine; OCT: 0.1% octenidine; PHMB: 0.1% polyhexanide; NaOCl: 0.6% sodium hypochlorite; H2O2: 1.5% hydrogen peroxide; EDTA: 20% ethylenediaminetetraacetic acid.