Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer

<table>uPA/uPAR signal transduction. The binding of uPA to uPAR can trigger the activation of intracellular signal transduction either by interacting with <i>α</i>5<i>β</i>1 integrin which allows the transactivation of EGFR by a mechanism mediated by FAK and Scr to in turn activate RAS-ERK1 MAPK, or by interacting with <i>α</i>6<i>β</i>1 integrin to also activate RAS-ERK signal.</table>

International Scholarly Research Notices

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Figure 2: Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer 