Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer

Figure 4

Integration of TGF-β signaling and transcription factor in the regulation of uPA/uPAR expression. Active TGF-β by binding to the receptors triggers the activation subsequent intracellular signaling, which in turn by activating transcription factors or inducing transcription factor complexes regulates uPA and uPAR expression, increasing the protein levels in cancer cells.