(a) A 51-year-old lady with underlying long-standing diabetes mellitus presented with large diabetic foot ulcer over her right foot dorsum, exposing extensor tendons and covered with slough tissue. (b) Regular dressings with chlorhexidine and serial bedside sharp debridement were performed to control local infection while optimizing her general and local conditions including blood sugar level. (c) Negative pressure wound therapy was applied for several cycles for wound bed pressure to achieve a vascularized wound bed covered healthy granulation tissue with advancing epithelialization. (d) The ulcer was successfully resurfaced with split skin graft and healed well without complication.