Review Article
Melanoma M (Zero): Diagnosis and Therapy
Table 4
Distribution of TNM staging according to pathologic and clinical features.
(a) |
| | Stage I | Stage II | T | | Not ulcerated | Ulcerated | Not ulcerated | ulcerated |
| 0 | | | | | 1 | A | B | | | 2 | A | | | B | 3 | | | A | B | 4 | | | A | C |
|
|
(b) |
| Stage III | T | Not ulcerated | Ulcerated |
| Metastasis 1 lymph node | Metastasis 1 lymph node | Micro A | Micro B | Macro B | Macro — |
| Metastasis 2 or 3 lymph node or intralymphatic | Metastasis 2 or 3 lymph node or intralymphatic | Micro A | Micro B | Macro B | Macro — | Intransit C | Intransit C |
| Metastasis 4/+ lymph node, matted metastatic node, in transit MT with MT in regional LN | Metastasis 4/+ lymph node, matted metastatic node, in transit MT with MT in regional LN | Micro — | Micro C | Macro — | Macro C |
|
|
(c) |
| Stage IV | LDH | Normal | Elevated |
| M1 | | | Skin, subcutaneous, node | A | C | Lung | B | C | Any other | C | C |
|
|
T1 ≤ 1 mm; T2 = 1,01–2,00 mm; T3 = 2,01–4,00 mm; T4 > 4,00 mm. A-B-C: indicator of substaging; LDH: lactate dehydrogenase; M: metastases.
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