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ISRN Cardiology
Volume 2013 (2013), Article ID 617943, 14 pages
http://dx.doi.org/10.1155/2013/617943
Review Article

Amiodarone-Induced Cirrhosis of Liver: What Predicts Mortality?

Department of Internal Medicine, Saint Joseph Hospital, Resurrection Health Care, 2900 North Lake Shore Drive, Chicago, IL 60657, USA

Received 18 January 2013; Accepted 11 February 2013

Academic Editors: A. Bobik, C. Hassager, and B. Strasberg

Copyright © 2013 Nasir Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Lewis, R. C. Ranard, A. Caruso et al., “Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients,” Hepatology, vol. 9, no. 5, pp. 679–685, 1989. View at Scopus
  2. S. R. Puli, M. A. Fraley, V. Puli, A. B. Kuperman, and M. A. Alpert, “Hepatic cirrhosis caused by low-dose oral amiodarone therapy,” American Journal of the Medical Sciences, vol. 330, no. 5, pp. 257–261, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Guigui, S. Perrot, J. P. Berry et al., “Amiodarone-induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease,” Hepatology, vol. 8, no. 5, pp. 1063–1068, 1988.
  4. J. H. Lewis, F. Mullick, K. G. Ishak et al., “Histopathologic analysis of suspected amiodarone hepatotoxicity,” Human Pathology, vol. 21, no. 1, pp. 59–67, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Atiq, J. C. Davis, L. W. Lamps, S. S. Beland, and J. E. Rose, “Amiodarone induced liver cirrhosis. Report of two cases,” Journal of Gastrointestinal and Liver Diseases, vol. 18, no. 2, pp. 233–235, 2009. View at Scopus
  6. B. Rigas, L. E. Rosenfeld, and K. W. Barwick, “Amiodarone hepatotoxicity. A clinicopathologic study of five patients,” Annals of Internal Medicine, vol. 104, no. 3, pp. 348–351, 1986. View at Scopus
  7. D. Capron-Chivrac, N. Reix, C. Quenum, and J. P. Capron, “Amiodarone hepatopathy. Study of a case and review of the literature,” Gastroenterologie Clinique et Biologique, vol. 9, no. 6-7, pp. 535–539, 1985. View at Scopus
  8. N. B. Chaabane, O. Hellara, L. Safer et al., “Cirrhosis with increased density of the liver: amiodarone-induced hepatotoxicity,” Tunisie Medicale, vol. 90, no. 6, pp. 487–488, 2012.
  9. http://livertox.nih.gov/Amiodarone.htm.
  10. M. Richer and S. Robert, “Fatal hepatotoxicity following oral administration of amiodarone,” Annals of Pharmacotherapy, vol. 29, no. 6, pp. 582–586, 1995. View at Scopus
  11. N. H. Gilinsky, G. W. Briscoe, and C. S. Kuo, “Fatal amiodarone hepatoxicity,” American Journal of Gastroenterology, vol. 83, no. 2, pp. 161–163, 1988. View at Scopus
  12. K. Tordjman, I. Katz, M. Brusztyn, and T. Rosenthal, “Amiodarone and the liver,” Annals of Internal Medicine, vol. 102, no. 3, pp. 411–412, 1985. View at Scopus
  13. J. M. Rene, J. Buenestado, B. Pais, and M. C. Pinol, “Cirrosis causada por amiodarona,” Revista Espanola de Enfermedades Digestivas, vol. 87, no. 5, pp. 399–402, 1995.
  14. A. Singhal, P. Ghosh, and S. A. Khan, “Low dose amiodarone causing pseudo-alcoholic cirrhosis,” Age and Ageing, vol. 32, no. 2, pp. 224–225, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Bach, B. L. Schultz, L. B. Cohen et al., “Amiodarone hepatotoxicity: progression from steatosis to cirrhosis,” Mount Sinai Journal of Medicine, vol. 56, no. 4, pp. 293–296, 1989. View at Scopus
  16. R. Martinez, E. Saperas, J. Vilaseca, P. Tornos, and H. Allende, “Cirrosis hepatica inducida por amiodarona,” Gastroenterologia y Hepatologia, vol. 17, no. 9, pp. 482–484, 1994.
  17. Ş. Çoban, S. Köklü, H. Sencer, F. Ekiz, and N. Örmeci, “Low dose amiodarone associated cirrhosis,” Journal of Gastroenterology and Hepatology, vol. 22, no. 1, pp. 140–141, 2007. View at Publisher · View at Google Scholar
  18. H. Oikawa, C. Maesawa, R. Sato et al., “Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: a case report,” World Journal of Gastroenterology, vol. 11, no. 34, pp. 5394–5397, 2005. View at Scopus
  19. A. Lamproye, J. Ramos, D. Larrey, and J. Belaiche, “Pseudo-alcoholic hepatitis and cirrhosis caused by Amiodarone (Cordarone),” Revue Médicale de Liège, vol. 53, pp. 120–124, 1998.
  20. G. Babany, A. Mallat, and E. S. Zafrani, “Chronic liver disease after low daily doses of amiodarone. Report of three cases,” Journal of Hepatology, vol. 3, no. 2, pp. 228–232, 1986. View at Scopus
  21. H. M. Rinder, J. C. Love, and R. Wexler, “Amiodarone hepatotoxicity,” The New England Journal of Medicine, vol. 314, no. 5, pp. 318–319, 1986. View at Scopus
  22. N. A. Shepherd, A. M. Dawson, P. R. Crocker, and D. A. Levison, “Granular cells as a marker of early amiodarone hepatotoxicity: a pathological and analytical study,” Journal of Clinical Pathology, vol. 40, no. 4, pp. 418–423, 1987. View at Scopus
  23. R. Jeyamalar, R. Pathmanathan, D. Wong, and P. Kannan, “Hepatotoxicity of amiodarone,” Annals of the Academy of Medicine Singapore, vol. 21, no. 6, pp. 838–840, 1992. View at Scopus
  24. S. Ishida, M. Sugino, T. Hosokawa et al., “Amiodarone-induced liver cirrhosis and parkinsonism: a case report,” Clinical Neuropathology, vol. 29, no. 2, pp. 84–88, 2010. View at Scopus
  25. R. F. Harrison and E. Elias, “Amiodarone-associated cirrhosis with hepatic and lymph node granulomas,” Histopathology, vol. 22, no. 1, pp. 80–82, 1993. View at Scopus
  26. K. Raja, S. N. Thung, M. I. Fiel, and C. Chang, “Drug-induced steatohepatitis leading to cirrhosis: long-term toxicity of amiodarone use,” Seminars in Liver Disease, vol. 29, no. 4, pp. 423–428, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. K. K. Flaharty, S. L. Chase, H. M. Yaghsezian, and R. Rubin, “Hepatotoxicity associated with amiodarone therapy,” Pharmacotherapy, vol. 9, no. 1, pp. 39–44, 1989. View at Scopus
  28. Y. Snir, N. Pick, K. Riesenberg, I. Yanai-Inbar, H. Zirkin, and F. Schlaeffer, “Fatal hepatic failure due to prolonged amiodarone treatment,” Journal of Clinical Gastroenterology, vol. 20, no. 3, pp. 265–266, 1995. View at Scopus
  29. C. C. Chang, M. Petrelli, J. F. Tomashefski, and A. J. McCullough, “Severe intrahepatic cholestasis caused by amiodarone toxicity after withdrawal of the drug: a case report and review of the literature,” Archives of Pathology and Laboratory Medicine, vol. 123, no. 3, pp. 251–256, 1999. View at Scopus
  30. P. S. Sung and S. K. Yoon, “Amiodarone hepatotoxicity,” Hepatology, vol. 55, no. 1, pp. 325–326, 2012. View at Publisher · View at Google Scholar
  31. S. Poucell, J. Ireton, and P. Valencia-Mayoral, “Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies,” Gastroenterology, vol. 86, no. 5 I, pp. 926–936, 1984. View at Scopus
  32. Z. Salti, P. Cloche, P. Weber, G. Houssemand, and F. Vollmer, “A case of amiodarone-induced cholestatic hepatitis,” Annales de Cardiologie et d'Angeiologie, vol. 38, no. 1, pp. 13–16, 1989. View at Scopus
  33. S. Chandraprakasam and M. Whitcraft, “Pseudo-alcoholic cirrhosis: an interesting case of amiodarone induced hepatotoxicity,” The Internet Journal of Gastroenterology, vol. 11, no. 1, 2012. View at Publisher · View at Google Scholar
  34. P. K. Lim, P. N. Trewby, G. C. A. Storey, and D. W. Holt, “Neuropathy and fatal hepatitis in a patient receiving amiodarone,” British Medical Journal, vol. 288, no. 6431, pp. 1638–1639, 1984. View at Scopus
  35. K. Itostetler, M. Reasor, and B. W. Frazee, “Mechanisms of amiodarone toxicity: inhibition of phospholipase A,” Circulation, vol. 79, p. 240, 1984.
  36. M. F. Heath, F. R. Costa-Jussa, J. M. Jacobs, and W. Jacobson, “The induction of pulmonary phospholipidosis and the inhibition of lysosomal phospholipases by amiodarone,” British Journal of Experimental Pathology, vol. 66, no. 4, pp. 391–397, 1985. View at Scopus
  37. R. Luallmann-Rauch and G. H. Reil, “Chlorphentermine-induced lipidosis-like ultrastructural alterations in lungs and adrenal glands of several species,” Toxicology and Applied Pharmacology, vol. 30, pp. 408–421, 1974. View at Publisher · View at Google Scholar
  38. M. Pirovino, O. Muller, T. Zysset, and U. Honegger, “Amiodarone-induced hepatic phospholipidosis: correlation of morphological and biochemical findings in an animal model,” Hepatology, vol. 8, no. 3, pp. 591–598, 1988. View at Scopus
  39. P. Yagupsky, E. Gazala, and S. Sofer, “Fatal hepatic failure and encephalopathy associated with amiodarone therapy,” Journal of Pediatrics, vol. 107, no. 6, pp. 967–970, 1985. View at Scopus
  40. A. Vereckei, E. Fehér, I. György et al., “Possibilities of antioxidant therapy in the prevention of side effects of amiodarone,” Orvosi Hetilap, vol. 132, no. 23, pp. 1265–1268, 1991. View at Scopus
  41. H. W. M. Breuer, W. Bossek, C. Haferland, M. Schmidt, H. Neumann, and J. Gruszka, “Amiodarone-induced severe hepatitis mediated by immunological mechanisms,” International Journal of Clinical Pharmacology and Therapeutics, vol. 36, no. 6, pp. 350–352, 1998. View at Scopus
  42. P. Kaufmann, M. Török, A. Hänni, P. Roberts, R. Gasser, and S. Krähenbühl, “Mechanisms of benzarone and benzbromarone-induced hepatic toxicity,” Hepatology, vol. 41, no. 4, pp. 925–935, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Fromenty, C. Fisch, G. Labbe et al., “Amiodarone inhibits the mitochondrial β-oxidation and fatty acids and produces microvesicular steatosis of the liver in mice,” Journal of Pharmacology and Experimental Therapeutics, vol. 255, no. 3, pp. 1371–1376, 1990. View at Scopus
  44. B. Fromenty, C. Fisch, A. Berson, P. Letteron, D. Larrey, and D. Pessayre, “Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II,” Journal of Pharmacology and Experimental Therapeutics, vol. 255, no. 3, pp. 1377–1384, 1990. View at Scopus
  45. P. T. Pollak, “How toxic is amiodarone to the liver?” Journal of Gastrointestinal and Liver Diseases, vol. 19, no. 1, pp. 11–13, 2010. View at Scopus
  46. S. H. Yap, P. J. M. Rijntjes, H. J. Moshage, H. Croes, and P. H. K. Jap, “Amiodarone-induced lysosomal inclusions in primary cultures of human hepatocytes,” Gastroenterology, vol. 92, no. 1, pp. 272–273, 1987. View at Scopus
  47. S. Kojima, S. Kojima, H. Ueno, M. Takeya, and H. Ogawa, “Increased density of the liver and amiodarone associated phospholipidosis,” Cardiol Res Pract, vol. 2009, Article ID 598940, 3 pages, 2009. View at Publisher · View at Google Scholar
  48. L. Llanos, R. Moreu, A. M. Peiró et al., “Causality assessment of liver injury after chronic oral amiodarone intake,” Pharmacoepidemiology and Drug Safety, vol. 18, no. 4, pp. 291–300, 2009. View at Publisher · View at Google Scholar
  49. J. Gill, R. C. Heel, and A. Fitton, “Amiodarone. An overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias,” Drugs, vol. 43, no. 1, pp. 69–110, 1992. View at Scopus
  50. P. C. Adams, M. K. Bennett, and D. W. Holt, “Hepatic effects of amiodarone,” British Journal of Clinical Practice. Supplement, vol. 44, pp. 81–95, 1986. View at Scopus
  51. J. B. Simon, P. N. Manley, J. F. Brien, and P. W. Armstrong, “Amiodarone hepatotoxicity simulating alcoholic liver disease,” The New England Journal of Medicine, vol. 311, no. 3, pp. 167–172, 1984. View at Scopus
  52. J. F. Brien, S. Jimmo, and F. J. Brennan, “Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues,” Canadian Journal of Physiology and Pharmacology, vol. 65, no. 3, pp. 360–364, 1987. View at Scopus
  53. P. Lettéron, A. Sutton, A. Mansouri, B. Fromenty, and D. Pessayre, “Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice,” Hepatology, vol. 38, no. 1, pp. 133–140, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. N. Gluck, M. Fried, and R. Porat, “Acute amiodarone liver toxicity likely due to Ischemic hepatitis,” Israel Medical Association Journal, vol. 13, no. 12, pp. 748–752, 2011.
  55. U. Klotz, “Antiarrhythmics: elimination and dosage considerations in hepatic impairment,” Clinical Pharmacokinetics, vol. 46, no. 12, pp. 985–996, 2007. View at Scopus
  56. D. S. Pratt and M. M. Kaplan, “Evaluation of abnormal liver-enzyme results in asymptomatic patients,” The New England Journal of Medicine, vol. 342, no. 17, pp. 1266–1271, 2000. View at Publisher · View at Google Scholar · View at Scopus
  57. W. Mattar, B. Juliar, I. Gradus-Pizlo, and P. Y. Kwo, “Amiodarone hepatotoxicity in the context of the metabolic syndrome and right-sided heart failure,” Journal of Gastrointestinal and Liver Diseases, vol. 18, no. 4, pp. 419–423, 2009. View at Scopus
  58. M. Babatin, S. S. Lee, and P. T. Pollak, “Amiodarone hepatotoxicity,” Current Vascular Pharmacology, vol. 6, no. 3, pp. 228–236, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. J. E. Tisdale, S. L. Follin, A. Ordelova, and C. R. Webb, “Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone,” Journal of Clinical Pharmacology, vol. 35, no. 4, pp. 351–356, 1995. View at Scopus
  60. L. C. C. Kum, W. W. L. Chan, H. H. Y. Hui et al., “Prevalence of amiodarone-related hepatotoxicity in 720 Chinese patients with or without baseline liver dysfunction,” Clinical Cardiology, vol. 29, no. 7, pp. 295–299, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. A. E. Rätz Bravo, J. Drewe, R. G. Schlienger, S. Krähenbühl, H. Pargger, and W. Ummenhofer, “Hepatotoxicity during rapid intravenous loading with amiodarone: description of three cases and review of the literature,” Critical Care Medicine, vol. 33, no. 1, pp. 128–134, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. P. T. Pollak and S. L. Shafer, “Use of population modeling to define rational monitoring of amiodarone hepatic effects,” Clinical Pharmacology and Therapeutics, vol. 75, no. 4, pp. 342–351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  63. C. Burgess, A. Blaikie, T. Ingham, G. Robinson, and S. Narasimhan, “Monitoring the use of amiodarone: compliance with guidelines,” Internal Medicine Journal, vol. 36, no. 5, pp. 289–293, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. P. T. Pollak and Y. D. You, “Monitoring of hepatic function during amiodarone therapy,” American Journal of Cardiology, vol. 91, no. 5, pp. 613–616, 2003. View at Publisher · View at Google Scholar · View at Scopus
  65. P. T. Pollak, A. D. Sharma, and S. G. Carruthers, “Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity,” American Journal of Cardiology, vol. 65, no. 18, pp. 1185–1191, 1990. View at Publisher · View at Google Scholar · View at Scopus
  66. P. J. Podrid, “Amiodarone: reevaluation of an old drug,” Annals of Internal Medicine, vol. 122, no. 9, pp. 689–700, 1995. View at Scopus