Chronic Phencyclidine Increases Synapsin-1 and Synaptic Adaptation Proteins in the Medial Prefrontal Cortex

Table 1

Summary of the proteins differentially expressed in the medial prefrontal cortex following phencyclidine treatment.

Protein		2D gel		Mass spectrometry
		Fold change	ANOVA; P value	MW (kDa)	pI	Score	Peptides in MS/MS
Upregulation by PCP
Syn1	Synapsin-1	1.3	0.0100	73.9	10	298.0	5
Dpysl3	Dihydropyrimidinase-related protein 3	1.2	0.0271	61.9	6.0	201.5	3
Aco2	Aconitate hydratase	1.1	0.0332	85.4	8.7	224.0	4
Fscn1	Fascin 1	1.2	0.0334	54.5	6.5	299.2	6
Tuba1c	Tubulin alpha-1C chain	1.2	0.0146	49.9	4.8	101.8	2
Mapk1	MAP kinase 1	1.3	0.0192	41.2	6.6	236.9	5
Trend to upregulation
Gnb4	Guanine nucleotide-binding protein subunit beta-4	1.2	0.0568	37.3	5.7	308.6	4
Capza2	F-actin-capping protein subunit alpha-2	1.2	0.0568	32.9	5.3	117.9	2
Downregulation by PCP
Bin1	Myc box-dependent-interacting protein 1	1.1	0.0185	64.4	4.8	413.6	7
Dpysl2	Dihydropyrimidinase-related protein 2	1.1	0.0286	62.2	5.9	224.5	6
Sugt1	Suppressor of G2 allele of SKP1 homolog	1.2	0.0389	38.1	5.0	234.6	4
ApoE	Apolipoprotein E	1.3	0.0002	35.7	5.1	260.0	5
Psme1	Proteasome activator complex subunit 1	1.1	0.0182	28.6	5.7	164.8	3
ERp29	Endoplasmic reticulum resident protein 29	1.1	0.0492	28.6	6.3	379.3	5
Pgam1	Phosphoglycerate mutase 1	1.1	0.0479	28.8	6.8	379.3	5
Uchl1	Ubiquitin carboxyl-terminal hydrolase isozyme L1	1.1	0.0313	24.8	5.0	597.4	5
Ndufv2	NADH dehydrogenase ubiquinone flavoprotein 2	1.1	0.0313	27.4	6.3	236.6	3
Pcmt1	Protein-L-isoaspartate (D-aspartate) O-methyltransferase	1.1	0.0068	24.6	7.9	197.1	4
Vdac1	Voltage-dependent anion-selective channel protein 1	1.1	0.0258	30.7	9.2	273.2	4
Trend to downregulation
EnoA	Alpha-enolase	1.1	0.0996	47.1	6.2	893.8	11
Fh	Fumarate hydratase	1.1	0.0754	54.3	9.7	185.8	2