Review Article

Risk of Cancer in Diabetes: The Effect of Metformin

Table 3

Role of AMPK in regulating energy balance at the whole body.

PancreasModulation of insulin secretion
LiverInhibition of gluconeogenesis
Inhibition of cholesterol synthesis
Adipose tissueInhibition of lipolysis
Skeletal muscleIncrease glucose uptake
Increase fatty acid oxidation
HypothalamusIncrease food intake
HeartIncrease glucose uptake
Increase fatty acid oxidation

AMPK: adenosine monophosphate kinase.