- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2013 (2013), Article ID 637897, 7 pages
Transsulfuration Is a Significant Source of Sulfur for Glutathione Production in Human Mammary Epithelial Cells
1Department of Chemistry, Marshall University, One John Marshall Drive, Huntington, WV 25755-0003, USA
2Department of Pharmacology, Physiology & Toxicology, Marshall University Joan C. Edwards School of Medicine, One John Marshall Drive, Huntington, WV 25755-0003, USA
3Department of Anatomy and Pathology, Marshall University Joan C. Edwards School of Medicine, One John Marshall Drive, Huntington, WV 25755-0003, USA
Received 22 January 2013; Accepted 16 February 2013
Academic Editors: A.-M. Lambeir and B. Lenarcic
Copyright © 2013 Andrea D. Belalcázar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. C. Lu, M. L. Martinez-Chantar, and J. M. Mato, “Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease,” Journal of Gastroenterology and Hepatology, vol. 21, supplement 3, pp. S61–S64, 2006.
- S. Ratnam, K. N. Maclean, R. L. Jacobs, M. E. Brosnan, J. P. Kraus, and J. T. Brosnan, “Hormonal regulation of cystathionine β-synthase expression in liver,” Journal of Biological Chemistry, vol. 277, no. 45, pp. 42912–42918, 2002.
- R. Banerjee, R. Evande, O. Kabil, S. Ojha, and S. Taoka, “Reaction mechanism and regulation of cystathionine beta-synthase,” Biochimica et Biophysica Acta, vol. 1647, no. 1-2, pp. 30–35, 2003.
- S. J. James, S. Melnyk, S. Jernigan et al., “Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism,” American Journal of Medical Genetics B, vol. 141, no. 8, pp. 947–956, 2006.
- S. Jill James, S. Melnyk, S. Jernigan, A. Hubanks, S. Rose, and D. W. Gaylor, “Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism,” Journal of Autism and Developmental Disorders, vol. 38, no. 10, pp. 1966–1975, 2008.
- D. A. Geier, J. K. Kern, C. R. Garver, J. B. Adams, T. Audhya, and M. R. Geier, “A prospective study of transsulfuration biomarkers in autistic disorders,” Neurochemical Research, vol. 34, no. 2, pp. 386–393, 2009.
- D. A. Geier, J. K. Kern, C. R. Garver et al., “Biomarkers of environmental toxicity and susceptibility in autism,” Journal of the Neurological Sciences, vol. 280, no. 1-2, pp. 101–108, 2009.
- S. J. James, S. Melnyk, G. Fuchs et al., “Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism,” American Journal of Clinical Nutrition, vol. 89, no. 1, pp. 425–430, 2009.
- J. H. Horowitz, E. B. Rypins, and J. M. Henderson, “Evidence for impairment of transsulfuration pathway in cirrhosis,” Gastroenterology, vol. 81, no. 4, pp. 668–675, 1981.
- C. Loguercio, G. Nardi, G. Prota, C. Del Vecchio Blanco, and M. Coltorti, “Decrease of total, glutathione and cysteine SH in non-alcoholic cirrhosis,” Italian Journal of Gastroenterology, vol. 22, no. 1, pp. 13–15, 1990.
- G. Marchesini, E. Bugianesi, G. Bianchi et al., “Defective methionine metabolism in cirrhosis: relation to severity of liver disease,” Hepatology, vol. 16, no. 1, pp. 149–155, 1992.
- M. P. Look, R. Riezler, C. Reichel et al., “Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of γ-cystathionase?” Scandinavian Journal of Gastroenterology, vol. 35, no. 8, pp. 866–872, 2000.
- G. Bianchi, M. Brizi, B. Rossi, M. Ronchi, G. Grossi, and G. Marchesini, “Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis,” Metabolism: Clinical and Experimental, vol. 49, no. 11, pp. 1434–1439, 2000.
- K. Robinson, E. Mayer, and D. W. Jacobsen, “Homocysteine and coronary artery disease,” Cleveland Clinic Journal of Medicine, vol. 61, no. 6, pp. 438–450, 1994.
- N. P. B. Dudman, X. W. Guo, R. B. Gordon, P. A. Dawson, and D. E. L. Wilcken, “Human homocysteine catabolism: three major pathways and their relevance to development of arterial occlusive disease,” Journal of Nutrition, vol. 126, supplement 4, pp. 1295S–1300S, 1996.
- P. Verhoef, M. J. Stampfer, J. E. Buring et al., “Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate,” American Journal of Epidemiology, vol. 143, no. 9, pp. 845–859, 1996.
- S. M. Saw, “Homocysteine and atherosclerotic disease: the epidemiologic evidence,” Annals of the Academy of Medicine Singapore, vol. 28, no. 4, pp. 565–568, 1999.
- P. Durand, M. Prost, N. Loreau, S. Lussier-Cacan, and D. Blache, “Impaired homocysteine metabolism and atherothrombotic disease,” Laboratory Investigation, vol. 81, no. 5, pp. 645–672, 2001.
- Y. Ingenbleek, D. Barclay, and H. Dirren, “Nutritional significance of alterations in serum amino acid patterns in goitrous patients,” American Journal of Clinical Nutrition, vol. 43, no. 2, pp. 310–319, 1986.
- G. Palareti, S. Salardi, and S. Piazzi, “Blood coagulation changes in homocystinuria: effects of pyridoxine and other specific therapy,” Journal of Pediatrics, vol. 109, no. 6, pp. 1001–1006, 1986.
- G. Palareti and S. Coccheri, “Lowered antithrombin III activity and other clotting changes in homocystinuria: effects of a pyridoxine-folate regimen,” Haemostasis, vol. 19, supplement 1, pp. 24–28, 1989.
- M. M. Eldibany and J. A. Caprini, “Hyperhomocysteinemia and thrombosis: an overview,” Archives of Pathology and Laboratory Medicine, vol. 131, no. 6, pp. 872–884, 2007.
- S. Garg, V. Vitvitsky, H. E. Gendelman, and R. Banerjee, “Monocyte differentiation, activation, and mycobacterial killing are linked to transsulfuration-dependent redox metabolism,” Journal of Biological Chemistry, vol. 281, no. 50, pp. 38712–38720, 2006.
- K. Wisniewski, J. A. Sturman, and E. Devine, “Cystathionine disappearance with neuronal loss: a possible neuronal marker,” Neuropediatrics, vol. 16, no. 3, pp. 126–130, 1985.
- F. Tchantchou, “Homocysteine increase folate oxidative brain homocysteine metabolism and various consequences of folate deficiency,” Journal of Alzheimer's Disease, vol. 9, no. 4, pp. 421–427, 2006.
- N. Vatanavicharn, B. D. Pressman, and W. R. Wilcox, “Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: a case report,” Journal of Inherited Metabolic Disease, 2007.
- S. H. Rahman, A. R. Srinivasan, and A. Nicolaou, “Transsulfuration pathway defects and increased glutathione degradation in severe acute pancreatitis,” Digestive Diseases and Sciences, vol. 54, no. 3, pp. 675–682, 2009.
- V. Vitvitsky, M. Thomas, A. Ghorpade, H. E. Gendelman, and R. Banerjee, “A functional transsulfuration pathway in the brain links to glutathione homeostasis,” Journal of Biological Chemistry, vol. 281, no. 47, pp. 35785–35793, 2006.
- J. A. Sturman, N. G. Beratis, L. Guarini, and G. E. Gaull, “Transsulfuration by human long term lymphoid lines. Normal and cystathionase-deficient cells,” Journal of Biological Chemistry, vol. 255, no. 10, pp. 4763–4765, 1980.
- S. H. Mudd, J. D. Finkelstein, F. Irreverre, and L. Laster, “Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway,” Journal of Biological Chemistry, vol. 240, no. 11, pp. 4382–4392, 1965.
- A. Ronco, E. De Stefani, M. Mendilaharsu, and H. Deneo-Pellegrini, “Meat, fat and risk of breast cancer: a case-control study from Uruguay,” International Journal of Cancer, vol. 65, no. 3, pp. 328–331, 1996.
- E. F. Taylor, V. J. Burley, D. C. Greenwood, and J. E. Cade, “Meat consumption and risk of breast cancer in the UK Women's Cohort Study,” British Journal of Cancer, vol. 96, no. 7, pp. 1139–1146, 2007.
- E. Cho, W. Y. Chen, D. J. Hunter et al., “Red meat intake and risk of breast cancer among premenopausal women,” Archives of Internal Medicine, vol. 166, no. 20, pp. 2253–2259, 2006.
- E. Linos, W. C. Willett, E. Cho, G. Colditz, and L. A. Frazier, “Red meat consumption during adolescence among premenopausal women and risk of breast cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 8, pp. 2146–2151, 2008.
- S. E. Steck, M. M. Gaudet, S. M. Eng et al., “Cooked meat and risk of breast cancer—lifetime versus recent dietary intake,” Epidemiology, vol. 18, no. 3, pp. 373–382, 2007.
- G. C. Kabat and T. E. Rohan, “Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis,” Cancer Causes and Control, vol. 18, no. 10, pp. 1047–1053, 2007.
- H. Takkunen and R. Seppanen, “Iron deficiency and dietary factors in Finland,” American Journal of Clinical Nutrition, vol. 28, no. 10, pp. 1141–1147, 1975.
- E. Bjorn Rasmussen, L. Hallberg, B. Isaksson, and B. Arvidsson, “Food iron absorption in man. Applications of the two pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet,” Journal of Clinical Investigation, vol. 53, no. 1, pp. 247–255, 1974.
- R. G. Dumitrescu and P. G. Shields, “The etiology of alcohol-induced breast cancer,” Alcohol, vol. 35, no. 3, pp. 213–225, 2005.
- V. Bagnardi, M. Blangiardo, C. L. Vecchia, and G. Corrao, “A meta-analysis of alcohol drinking and cancer risk,” British Journal of Cancer, vol. 85, no. 11, pp. 1700–1705, 2001.
- Collaborative Group on Hormonal Factors in Breast Cancer, “Alcohol, tobacco and breast cancer—collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease,” British Journal of Cancer, vol. 87, no. 11, pp. 1234–1245, 2002.
- R. Suzuki, N. Orsini, L. Mignone, S. Saji, and A. Wolk, “Alcohol intake and risk of breast cancer defined by estrogen and progesterone receptor status—ameta-analysis of epidemiological studies,” International Journal of Cancer, vol. 122, no. 8, pp. 1832–1841, 2008.
- H. Kamencic, A. Lyon, P. G. Paterson, and B. H. J. Juurlink, “Monochlorobimane fluorometric method to measure tissue glutathione,” Analytical Biochemistry, vol. 286, no. 1, pp. 35–37, 2000.
- J. C. Fernandez-Checa and N. Kaplowitz, “The use of monochlorobimane to determine hepatic GSH levels and synthesis,” Analytical Biochemistry, vol. 190, no. 2, pp. 212–219, 1990.
- O. W. Griffith, “Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine,” Analytical Biochemistry, vol. 106, no. 1, pp. 207–212, 1980.
- M. E. Anderson, “Determination of glutathione and glutathione disulfide in biological samples,” Methods in Enzymology, vol. 113, pp. 548–555, 1985.
- M. Valentovic, M. K. Meadows, R. C. Harmon, J. G. Ball, S. K. Hong, and G. O. Rankin, “2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: effect of antioxidants and sulfhydryl agents,” Toxicology and Applied Pharmacology, vol. 161, no. 1, pp. 1–9, 1999.
- M. A. Valentovic, J. G. Ball, H. Sun, and G. O. Rankin, “Characterization of 2-amino-4,5-dichlorophenol (2A45CP) in vitro toxicity in renal cortical slices from male Fischer 344 rats,” Toxicology, vol. 172, no. 2, pp. 113–123, 2002.
- M. Valentovic, M. Terneus, R. C. Harmon, and A. B. Carpenter, “S-Adenosylmethionine (SAMe) attenuates acetaminophen hepatotoxicity in C57BL/6 mice,” Toxicology Letters, vol. 154, no. 3, pp. 165–174, 2004.
- R. C. Harmon, M. V. Terneus, K. K. Kiningham, and M. Valentovic, “Time-dependent effect of p-Aminophenol (PAP) toxicity in renal slices and development of oxidative stress,” Toxicology and Applied Pharmacology, vol. 209, no. 1, pp. 86–94, 2005.
- R. C. Harmon, K. K. Kiningham, and M. A. Valentovic, “Pyruvate reduces 4-aminophenol in vitro toxicity,” Toxicology and Applied Pharmacology, vol. 213, no. 2, pp. 179–186, 2006.
- M. V. Terneus, K. K. Kiningham, A. B. Carpenter, S. B. Sullivan, and M. A. Valentovic, “Comparison of S-adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity,” Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 1, pp. 99–107, 2007.
- M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976.
- L. Bao, Č. Vlček, V. Pačes, and J. P. Kraus, “Identification and tissue distribution of human cystathionine β-synthase mRNA isoforms,” Archives of Biochemistry and Biophysics, vol. 350, no. 1, pp. 95–103, 1998.
- K. Lertratanangkoon, C. J. Wu, N. Savaraj, and M. L. Thomas, “Alterations of DNA methylation by glutathione depletion,” Cancer Letters, vol. 120, no. 2, pp. 149–156, 1997.
- E. Mosharov, M. R. Cranford, and R. Banerjee, “The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes,” Biochemistry, vol. 39, no. 42, pp. 13005–13011, 2000.
- R. C. Bakker and D. P. M. Brandjes, “Hyperhomocysteinaemia and associated disease,” Pharmacy World and Science, vol. 19, no. 3, pp. 126–132, 1997.
- C. P. Lima, S. R. Davis, A. D. Mackey, J. B. Scheer, J. Williamson, and J. F. Gregory, “Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets,” Journal of Nutrition, vol. 136, no. 8, pp. 2141–2147, 2006.
- B. Tang, A. Mustafa, S. Gupta, S. Melnyk, S. J. James, and W. D. Kruger, “Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase,” Nutrition, vol. 26, no. 11-12, pp. 1170–1175, 2010.