Clinical Study

Epidemiology and Prognosis of Paraneoplastic Syndromes in Hepatocellular Carcinoma

Table 2

Prognostic variables in HCC patients with and without paraneoplastic syndromes (PNS).

Prognostic variableWith PNS ( )Without PNS ( )

Young age (≤40 years)13 (10.2%)28 (8.5%)NS
AFP ≥ 12,000  g/L59 (46.5%)88 (26.7%)<0.001
Bilobar disease73 (57.5%)158 (47.9%)NS
Multiple lesions92 (72.4%)216 (65.5%)NS
Portal vein invasion64 (50.4%)141 (50.9%)NS
Distant metastases28 (22.0%)59 (17.9%)NS
TNM stage (I&II/III&IV)25/102 (19.7%/80.3%)110/220 (33.3%/66.7%)0.017
Child-Pugh A/B/C 57/53/17 (44.9%/41.7%/13.4%)146/135/49 (44.2%/40.9%/14.8%)NS

PNS: paraneoplastic syndromes; NS: not statistically significant ( ).