The Role of Chronic Inflammation in Obesity-Associated Cancers

Figure 3

Signals emanating from the white adipose tissue. ASP: acylation-stimulating protein; aP2: activating protein 2; apoE: apolipoprotein E; RBP4: retinol binding protein 4; RAS: rennin-angiotensin system; NO synthase: nitric oxide synthase; IGF-1: insulin-like growth factor 1; FGF: fibroblast growth factor; HGF: hepatocyte growth factor; NGF: nerve growth factor; VEGF: vascular endothelial growth factor; TGFβ: transforming growth factor beta; TF: tissue factor; SDF-1: stromal derived factor; PGF: placental growth factor; VCAM-1: vascular cell adhesion molecule 1; ICAM-1: intracellular adhesion molecule 1; MMPs: matrix metalloproteinase proteins; TIMPs: tissue inhibitor of metalloproteinase; IL: interleukin; TNFα: tumor necrosis factor alpha; MIF: macrophage migrating inhibitor factor; MCP-1: monocyte chemotactic protein-1; MIP-1α: macrophage inflammatory protein 1; RANTES: Regulated on Activation, Normal T cell Expressed and Secreted; CRP: C-reactive protein; SAA3: serum amyloid A3; PAI-1: plasminogen activator-1.