Effective Single-Step Posttranscriptional Dynamics Allowing for a Direct Maximum Likelihood Estimation of Transcriptional Activity and the Quantification of Sources of Gene Expression Variability with an Illustration for the Hypoxia and TNFα Regulated Inflammatory Pathway

Table 1

Correlation coefficients of lag-1 of the residuals defined by (37) under the four stimulation conditions. In the first column, the threshold given indicates the statistically significant correlations (at a significance level of 0.05). Values below that threshold are considered not to be significant.

Threshold 2/(𝑅⋅𝑁)^1/2 with 𝑅=8, 𝑁=4	Baseline (Normoxia and 0 ng/mL TNF𝛼)	TNFα stimulation (Normoxia and 1 ng/mL TNF𝛼)	Hypoxia stimulation (Hypoxia and 0 ng/mL TNF𝛼)	Dual (Hypoxia and 1 ng/mL TNF𝛼)
0.35	0.02	0.22	0.10	0.35