Research Article

Effective Single-Step Posttranscriptional Dynamics Allowing for a Direct Maximum Likelihood Estimation of Transcriptional Activity and the Quantification of Sources of Gene Expression Variability with an Illustration for the Hypoxia and TNFα Regulated Inflammatory Pathway

Table 2

Sample means of estimated drift parameters (transcription rates) under various experimental conditions. SDs in brackets are SDs from actual sample sizes (i.e., SDs calculated before mean substitution of missing data). Data presented in arbitrary units (relative light units per hour).

Normoxia
21% oxygen
Hypoxia
1% oxygen

0 ng/mL TNF 0.11 (0.05)0.30 (0.05)
0.1 ng/mL TNF 0.27 (0.01)0.45 (0.14)
1.0 ng/mL TNF 0.30 (0.13)0.87 (0.25)