Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone
Figure 2
Lower doses of CTX (50 mg/kg or 100 mg/kg × 7 days) did not produce a visceromotor response different from the control group at graded distension volumes. Animals administered 1 wk VEH + intravesicular acrolein (ivc ACRO) showed a significant increase in the visceromotor response compared to the control group at 0.15 and 0.2 mL (*). In contrast, mice treated with 1 wk CTX (50 or 100 mg/kg) + ivc ACRO did not show an enhanced visceromotor response to bladder distension compared to the 1 wk VEH + ivc VEH treated cohort at 0.15 and 0.2 mL.
