Design and Development of Novel Dual-Compartment Capsule for Improved Gastroretention

Table 4

Mathematical models for different formulations.

Formulation code	Correlation coefficient (𝑟^2)					Release exponent (𝑛)	Best fit model
	Zero order	First order	Higuchi	Korsmeyer-Peppas	Hixson-Crowell
FA1	0.947	0.924	0.975	0.993	0.690	0.8086	Korsmeyer-Peppas
FA2	0.857	0.973	0.965	0.977	0.587	0.6494	Korsmeyer-Peppas
FE1	0.917	0.988	0.979	0.994	0.642	0.6593	Korsmeyer-Peppas
FE2	0.909	0.875	0.995	0.971	0.566	0.4996	Higuchi
FK1	0.943	0.959	0.986	0.998	0.607	0.5318	Korsmeyer-Peppas
FK2	0.970	0.974	0.962	0.990	0.645	0.5511	Korsmeyer-Peppas
FC1	0.929	0.951	0.949	0.977	0.949	0.4786	Korsmeyer-Peppas
FC2	0.935	0.853	0.965	0.975	0.965	0.5089	Korsmeyer-Peppas
FG1	0.919	0.893	0.850	0.968	0.684	0.5764	Korsmeyer-Peppas
FG2	0.990	0.988	0.953	0.993	0.717	0.6751	Korsmeyer-Peppas
FX1	0.847	0.957	0.965	0.975	0.559	0.5291	Korsmeyer-Peppas
FX2	0.897	0.892	0.994	0.967	0.560	0.4870	Higuchi