Development of a Closed Chest Model of Chronic Myocardial Infarction in Swine: Magnetic Resonance Imaging and Pathological Evaluation

Figure 2

Cardiac MR images obtained during the study. Cine images obtained in short axis and four chamber views at all timepoints are shown in the first two rows. The third row depicts delayed enhanced acquisitions. (a) and (b) Baseline examinations showing normal swine cardiac anatomy. (c), (d) and (e) Images acquired immediately after infarct induction. The infarcted area can be identified by a density change in the cine images, which correspond to the enhanced area on the viability study. (f), (g) and (h) Images obtained 7 days after infarction. Little changes were evidenced in the cine images at this timepoint (apart from akinesia of the septum), but the DE view shows the typical hyperenhancement appearance of the infarct. (i), (j) and (k) Study performed on the 30-day followup. Wall thickness is clearly decreased in the infarcted area (anteroseptal), corresponding with the hyperenhanced septum in the viability study. (l), (m) and (n): 90-day followup. The infarcted area is clearly identified as a very thin wall in the cine acquisitions and as a highly enhanced area in the viability study.