Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn

Table 3

Protective effect of Centella asiatica extracts (methanol and chloroform) on tail withdrawal reflexes induced by tail flick method in mice.

Drugs (dose)	Methanol			Chloroform
	Before treatment (sec)	After treatment (sec)	% Inhibition	After treatment (sec)	% Inhibition
Control (saline)	5.53±0.15	5.53±0.15	0.00	5.53±0.15	0.00
Dextropropoxyphene (65 mg/kg)	5.58±0.35	10.74±0.52^b	48.04	10.74±0.52^b	48.04
Extract (50 mg/kg)	5.57±0.19	6.64±0.19^a	16.11	6.34±0.56^a	12.14
Extract (100 mg/kg)	6.06±0.37	7.73±0.45^a	21.60	7.05±0.44^a	14.04
Extract (200 mg/kg)	6.07±0.33	8.45±0.54^a	28.16	8.63±0.40^a	29.66

Values are mean ± SEM (𝑛=6). Differences in groups were analyzed by one-way analysis of variances (one-way ANOVA) followed by Bonferroni posttest. ^a𝑃<0.05 and ^b𝑃<0.001 represented highly significant compared to control.