Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn

Table 5

Protective effect of Centella asiatica extracts (methanol and chloroform) on tail withdrawal reflexes induced by tail clip method in mice.

Drugs (dose)	Methanol			Chloroform
	Before treatment (sec)	After treatment (sec)	% Inhibition	After treatment (sec)	% Inhibition
Control (saline)	1.27±0.07	1.27±0.07	0.00	1.27±0.07	0.00
Dextropropoxyphene (65 mg/kg)	1.21±0.06	3.17±0.12^b	61.82	3.17±0.12^b	61.82
Extract (50 mg/kg)	1.34±0.04	1.37±0.08^a	2.18	1.61±0.05^a	16.77
Extract (100 mg/kg)	1.45±0.09	2.63±0.17^b	44.86	2.68±0.17^b	45.89
Extract (200 mg/kg)	1.16±0.82	2.38±0.14^b	51.26	2.58±0.11^b	55.03

Values are mean ± SEM (𝑛=6). Differences in groups were analyzed by one-way analysis of variances (one-way ANOVA) followed by Bonferroni posttest. ^a𝑃<0.05 and ^b𝑃<0.001 represented highly significant compared to control.