Spectrophotometric Determination of Zolmitriptan in Bulk Drug and Pharmaceuticals Using Vanillin as a Reagent

Table 1

Regression and analytical parameters.

Parameter	Proposed method
𝜆max, nm	580
Beer’s law limits (𝜇g mL^−1)	5.0–90.0
Molar absorptivity (L mol^−1 cm^−1)	3.3 × 10^3
Sandell sensitivity* (𝜇g cm^−2)	0.0872
Limit of detection (𝜇g mL^−1)	1.26
Limit of quantification (𝜇g mL^−1)	3.81
Regression equation, 𝑌** Intercept, (𝑎)	−0.0101
Slope, (𝑏)	0.0117
Correlation coefficient (𝑟)	0.9994
Standard deviation of intercept (𝑆𝑎)	0.0098
Standard deviation of slope (𝑆𝑏)	0.0002

*Limit of determination as the weight in µg per mL of solution, which corresponds to an absorbance of A = 0.001 measured in a cuvette of cross-sectional area 1 cm² and l = 1 cm. **𝑌=𝑎+𝑏𝑋, where 𝑌 is the absorbance, a is the intercept, b is the slope, and 𝑋 is the concentration in 𝜇g mL⁻¹.