- About this Journal ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2013 (2013), Article ID 794962, 8 pages
Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients
Department of Immunology, National Institute of Research in Tuberculosis (ICMR), Mayor V.R. Ramanathan Road, Chetput,
Chennai, Tamil Nadu 600 031, India
Received 27 May 2013; Accepted 5 July 2013
Academic Editors: C. M. Artlett and A. Taylor-Robinson
Copyright © 2013 Basirudeen Syed Ahamed Kabeer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- WHO, 2008, Tuberculosis Facts. Stop TB partnership, pp 1-2, http://www.who.int/tb/publications/2008/factsheet_april08.pdf.
- L. Goldsack and J. R. Kirman, “Half-truths and selective memory: interferon gamma, CD4+ T cells and protective memory against tuberculosis,” Tuberculosis, vol. 87, no. 6, pp. 465–473, 2007.
- J. L. Flynn, “Immunology of tuberculosis and implications in vaccine development,” Tuberculosis, vol. 84, no. 1-2, pp. 93–101, 2004.
- E. van de Vosse, M. A. Hoeve, and T. H. M. Ottenhoff, “Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae,” The Lancet Infectious Diseases, vol. 4, no. 12, pp. 739–749, 2004.
- O. Filipe-Santos, J. Bustamante, A. Chapgier et al., “Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features,” Seminars in Immunology, vol. 18, pp. 347–361, 2006.
- D. L. Barber, E. J. Wherry, D. Masopust et al., “Restoring function in exhausted CD8 T cells during chronic viral infection,” Nature, vol. 439, no. 7077, pp. 682–687, 2006.
- S. D. Blackburn, H. Shin, W. N. Haining et al., “Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection,” Nature Immunology, vol. 10, no. 1, pp. 29–37, 2009.
- C. L. Day, D. E. Kaufmann, P. Kiepiela et al., “PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression,” Nature, vol. 443, no. 7109, pp. 350–354, 2006.
- R. B. Jones, L. C. Ndhlovu, J. D. Barbour et al., “Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection,” Journal of Experimental Medicine, vol. 205, no. 12, pp. 2763–2779, 2008.
- D. E. Kaufmann, D. G. Kavanagh, F. Pereyra et al., “Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction,” Nature Immunology, vol. 8, no. 11, pp. 1246–1254, 2007.
- S. Urbani, B. Amadei, D. Tola et al., “PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion,” Journal of Virology, vol. 80, no. 22, pp. 11398–11403, 2006.
- S. Kannanganat, C. Ibegbu, L. Chennareddi, H. L. Robinson, and R. R. Amara, “Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells,” Journal of Virology, vol. 81, no. 16, pp. 8468–8476, 2007.
- G. Makedonas and M. R. Betts, “Living in a house of cards: Re-evaluating CD8+ T-cell immune correlates against HIV,” Immunological Reviews, vol. 239, no. 1, pp. 109–124, 2011.
- S. Kannanganat, B. G. Kapogiannis, C. Ibegbu et al., “Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines,” Journal of Virology, vol. 81, no. 21, pp. 12071–12076, 2007.
- M. R. Betts, M. C. Nason, S. M. West et al., “HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells,” Blood, vol. 107, no. 12, pp. 4781–4789, 2006.
- D. Ciuffreda, D. Comte, M. Cavassini et al., “Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication,” European Journal of Immunology, vol. 38, no. 10, pp. 2665–2677, 2008.
- P. A. Darrah, D. T. Patel, P. M. De Luca et al., “Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major,” Nature Medicine, vol. 13, no. 7, pp. 843–850, 2007.
- E. K. Forbes, C. Sander, E. O. Ronan et al., “Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice,” Journal of Immunology, vol. 181, no. 7, pp. 4955–4964, 2008.
- N. Caccamo, G. Guggino, S. A. Joosten et al., “Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection,” European Journal of Immunology, vol. 40, no. 8, pp. 2211–2220, 2010.
- C. L. Day, N. Mkhwanazi, S. Reddy et al., “Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons,” Journal of Infectious Diseases, vol. 197, no. 7, pp. 990–999, 2008.
- J. M. Young, I. M. O. Adetifa, M. O. C. Ota, and J. S. Sutherland, “Expanded polyfunctional T cell response to mycobacterial antigens in TB disease and contraction post-treatment,” PLoS ONE, vol. 5, no. 6, Article ID e11237, 2010.
- K. A. Millington, J. A. Innes, S. Hackforth et al., “Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load,” Journal of Immunology, vol. 178, no. 8, pp. 5217–5226, 2007.
- M. Kumar, N. Meenakshi, J. C. Sundaramurthi, G. Kaur, N. K. Mehra, and A. Raja, “Immune response to Mycobacterium tuberculosis specific antigen ESAT-6 among south Indians,” Tuberculosis, vol. 90, no. 1, pp. 60–69, 2010.
- M. Kumar, J. C. Sundaramurthi, N. K. Mehra, G. Kaur, and A. Raja, “Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in South India,” Medical Microbiology and Immunology, vol. 199, no. 1, pp. 11–25, 2010.
- A. Harari, V. Rozot, F. B. Enders et al., “Dominant TNF-α+Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease,” Nature Medicine, vol. 17, no. 3, pp. 372–376, 2011.
- A. J. Zajac, J. N. Blattman, K. Murali-Krishna et al., “Viral immune evasion due to persistence of activated T cells without effector function,” Journal of Experimental Medicine, vol. 188, no. 12, pp. 2205–2213, 1998.
- M. Lucas, C. L. Day, J. R. Wyer et al., “Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells,” Journal of Virology, vol. 78, no. 13, pp. 7284–7287, 2004.
- J. P. Casazza, M. R. Betts, D. A. Price et al., “Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation,” Journal of Experimental Medicine, vol. 203, no. 13, pp. 2865–2877, 2006.
- S. C. Derrick, I. M. Yabe, A. Yang, and S. L. Morris, “Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells,” Vaccine, vol. 29, no. 16, pp. 2902–2909, 2011.
- P. Klenerman and A. Hill, “T cells and viral persistence: lessons from diverse infections,” Nature Immunology, vol. 6, no. 9, pp. 873–879, 2005.
- A. Harari, S. Petitpierre, F. Vallelian, and G. Pantaleo, “Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy,” Blood, vol. 103, no. 3, pp. 966–972, 2004.
- C. L. Day, D. A. Abrahams, L. Lerumo et al., “Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load,” Journal of Immunology, vol. 187, no. 5, pp. 2222–2232, 2011.
- U. Sester, M. Fousse, J. Dirks et al., “Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states,” PLoS ONE, vol. 6, no. 3, Article ID e17813, 2011.
- D. Goletti, O. Butera, F. Bizzoni, R. Casetti, E. Giradi, and F. Poccia, “Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis,” Journal of Infectious Diseases, vol. 194, no. 7, pp. 984–992, 2006.