
S. no.  Research envisaged  Instrumental technique  Chemometric analysis  Reference 

(1)  Highthroughput NIRchemometric method for meloxicam assay from powder blends for tableting  NIR spectroscopy  Principal component regression (PCR) and partial least squares (PLS) regression  [38] 
(2)  Selfmodeling curve resolution (SMCR) analysis of nearinfrared (NIR) imaging data of pharmaceutical tablets  NIR  Selfmodelling curve resolution (SMCR) analysis  [39] 
(3)  Measurement of soluble solids contents and pH in orange juice using chemometrics and Vis/NIRS  Visible and near infrared reflectance spectroscopy  Partial least squares  [40] 
(4)  Formulation and evaluation of proteinloaded solid dispersions by nondestructive methods  Powder Xray diffraction (PXRD), near infrared chemical imaging (NIRCI)  Principal component analysis and partial least square regression  [43] 
(5)  Water content determination of super disintegrants by means of ATRFTIR spectroscopy.  ATRFTIR spectroscopy  Simple linear regression  [56] 
(6)  Chemometric determination of naproxen sodium and pseudoephedrine hydrochloride in tablets by HPLC.  HPLC  Classical least squares (CLS), principle component regression (PCR), and partial least squares (PLS)  [46] 
(7)  Simultaneous determination of ambroxol hydrochloride and guaifenesin by HPLC, TLCspectrodensitometric, and multivariate calibration methods in pure form and in cough cold formulations  HPLC, TLCspectrodensitometric  Multivariate calibration methods  [47] 
(8)  Quantification of meloxicam & excipients on intact tablets by near infrared spectrometry and chemometrics  Nearinfrared Spectroscopy, HPLC  Partial leastsquares (PLS) and principal component regression (PCR) methods  [48] 
(9)  Determination of flow properties of pharmaceutical powders by near infrared spectroscopy  NIR spectroscopy  Partial least square  [53] 
(10)  Accurate determination of polyethylene pellet density using transmission Raman spectroscopy  Transmission Raman Spectroscopy  Principal component analysis  [54] 
(11)  Chemometric evaluation of pharmaceutical properties of antipyrine granules by nearinfrared spectroscopy  Nearinfrared Spectroscopy  Principal component regression (PCR) analysis  [55] 
(12)  Investigation of preparation parameters to improve the dissolution of poorly watersoluble meloxicam  Xray powder diffraction  Selfmodelling curve resolution method  [57] 
(13)  Theoretical analysis of tablet hardness prediction usingchemoinformetricnearinfrared spectroscopy  Nearinfrared Spectroscopy  Principal component regression (PCR) analysis  [58] 
(14)  Prediction of tablet properties based on near infrared spectra of raw mixed powders by chemometrics: scaleup factor of blending and tableting processes  Nearinfrared Spectroscopy  Principal component regression (PCR) method  [59] 
(15)  Predicting the drug concentration in starch acetate matrix tablets from ATRFTIR spectra using multiway methods  ATRFTIR  Parallel factor analysis (PARAFAC) and multilinear partial least squares (NPLS)  [60] 
(16)  An efficient method development strategy for the quantitative chemical imaging using terahertz pulse spectroscopy  Terahertz pulse spectroscopy  Partial least square type 2 regression  [61] 
(17)  Fluorescence spectroscopic determination of triglyceride in human serum with window genetic algorithm partial least squares  Fluorescence spectroscopy  Nonlinear partial least squares (NLPLS); window genetic algorithms partial least squares (WGAPLS)  [62] 
