Brain Physiology and Pathophysiology in Mental Stress

Table 1

Effects of chronic psychosocial stress on cellular and molecular neuronal functions in at-risk AD model in rats. Sub-Aβ (160 pmol/day; subpathogenic dose); Full Aβ (300 pmol/day; pathogenic dose) in CA1 area of the hippocampus; ⇓ decreased; ⇑ increased; ⇔ no change compared to the control. Note that Sub-Aβ values are identical to control values (not shown) and that the presence of stress in sub-Aβ rats revealed full AD phenotype seen in Full Aβ.

	Stress	Sub-A𝛽	Str/sub-A𝛽	Full A𝛽
P-CaMKII	⇓	⇔	⇓	⇓
t-CaMKII	⇔	⇔	⇔	⇔
Calcineurin	⇑	⇔	⇑	⇑
BDNF	⇔	⇑	⇑	⇑
P-CREB	⇔	⇔	⇓	⇓
t-CREB	⇔	⇔	⇔	⇔
CaMKIV	⇔	⇔	⇓	⇓
Learning	⇔	⇔	⇓	⇓
Short-term memory	⇓	⇔	⇓⇓	⇓
Long-term memory	⇔	⇔	⇓	⇓
Early LTP magnitude	⇓	⇔	⇓	⇓
Late LTP magnitude	⇔	⇔	⇓	⇓
LTD magnitude	⇑	⇔	⇑⇑	⇑⇑