Table 1: Effects of chronic psychosocial stress on cellular and molecular neuronal functions in at-risk AD model in rats. Sub-Aβ (160 pmol/day; subpathogenic dose); Full Aβ (300 pmol/day; pathogenic dose) in CA1 area of the hippocampus; decreased; increased; no change compared to the control. Note that Sub-Aβ values are identical to control values (not shown) and that the presence of stress in sub-Aβ rats revealed full AD phenotype seen in Full Aβ.

StressSub-A Str/sub-A Full A

P-CaMKII
t-CaMKII
Calcineurin
BDNF
P-CREB
t-CREB
CaMKIV
Learning
Short-term memory
Long-term memory
Early LTP magnitude
Late LTP magnitude
LTD magnitude