Clinical Presentation, Pathogenesis, Diagnosis, and Treatment of Epidermolysis Bullosa Acquisita

<table>Modulation of complement-driven inflammation through FcgRIIB and dectin-1. Highly galactosylation IgG1 immune complexes bind to FcgRIIB. Galactosylation links FcgRIIB to dectin-1 resulting in tyrosine phosphorylation of the ITAM-like motif downstream of dectin-1 and transient phosphorylation of Syk. This pathway inhibits C5a-mediated ERK1/2 phosphorylation and several cellular effector functions of C5aR.</table>

International Scholarly Research Notices

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Figure 5

Figure 5: Clinical Presentation, Pathogenesis, Diagnosis, and Treatment of Epidermolysis Bullosa Acquisita 