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International Scholarly Research Notices
Table of Contents
International Scholarly Research Notices
/
2013
/
Article
/
Tab 5
/
Review Article
Clinical Presentation, Pathogenesis, Diagnosis, and Treatment of Epidermolysis Bullosa Acquisita
Table 5
Cytokine expression in experimental EBA.
Cytokine
Serum concentration
Cutaneous expression
Functional relevance
Reference
TNF-
↑
↑
Proinflammatory (very moderate)
Unpublished
MIP-1
↑
↑
none
Unpublished
GM-CSF
↑
↑
Proinflammatory (strong)
[
128
]
G-CSF
—
—
nd
IL-1
↑
↑
Proinflammatory
[
123
]
IL-1
↑
↑
Proinflammatory
[
123
]
IL-2
Below detection limit
—
nd
IL-3
—
—
nd
IL-4
↑
nd
nd
IL-5
—
nd
nd
IL-6
↑
↑
Anti-inflammatory
[
123
]
IL-9
—
nd
nd
IL-10
↑
nd
nd
IL-12
—
nd
nd
IL-13
—
nd
nd
IL-17
↑
nd
nd
IL-24
nd
↑
nd
Eotaxin
—
nd
nd
RANTES
↑
nd
nd
IFN-
—
nd
nd
MCP-1
—
nd
nd
CXCL1 and CXCL2
↑
↑
Proinflammatory
[
127
]
CXCL3
nd
↑
nd
CXCL5
nd
↑
nd
Expression data is obtained from Samavedam et al. and from Kasperkiewicz et al. [
123
,
124
]. Functional relevance was evaluated in the indicated publications. “↑”; “—” indicates statistically not significant difference in expression; “nd”: not done.