Table 2: Expression of cytoplasmic and membrane-bound guanylate cyclases.

Cyclases Tissue distribution Agonists

Cytoplasmic Skeletal muscle, platelets, lung, liver, kidney, heart, and CNS NO, CO
GC-ASmooth muscle, kidney, adrenal gland, heart, and CNS ANP, BNP
GC-B Fibroblasts, heart, and CNS CNP
GC-C Intestine, adrenal gland, CNS, lung, reproductive glands, and kidney STa, GN, and UGN
GC-D Olfactory cells GN, UGN
GC-E Retina Unknown
GC-F Retina Unknown
GC-GSkeletal muscle, lung, intestine, and kidney Unknown

ANP: atrial natriuretic peptide, BNP: brain natriuretic peptide, CNP: C-type natriuretic peptide, CNS: central nervous system, CO: carbon monoxide, NO: nitric oxide, STa: heat-stable enterotoxin of Escherichia coli, GN: guanylin, and UGN: uroguanylin.