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ISRN Genetics
Volume 2013 (2013), Article ID 837202, 5 pages
http://dx.doi.org/10.5402/2013/837202
Research Article

Cuban Adolescents Requesting Presymptomatic Testing for Spinocerebellar Ataxia Type 2

1Predictive Genetics Department, Center for the Research and Rehabilitation of Hereditary Ataxias, Reparto Edecio Pérez, CP 80100 Holguín, Cuba
2Neurophysiology Department, Center for the Research and Rehabilitation of Hereditary Ataxias, Reparto Edecio Pérez, CP 80100 Holguín, Cuba
3Molecular Biology Department, Center for the Research and Rehabilitation of Hereditary Ataxias, Reparto Edecio Pérez, CP 80100 Holguín, Cuba
4Clinical Department, Center for the Research and Rehabilitation of Hereditary Ataxias, Reparto Edecio Pérez, CP 80100 Holguín, Cuba
5International Relationships Department, Medical University of Holguín, CP 80100 Holguín, Cuba
6Center for Predictive and Preventive Genetics IBMC, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal

Received 23 March 2013; Accepted 12 April 2013

Academic Editors: D. Radojkovic and W. Wang

Copyright © 2013 Tania Cruz-Mariño et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Since 2001 a program for the presymptomatic testing of families affected with SCA2 has been under development in Cuba. According to the initial protocol, access would be given to nonsymptomatic individuals at 50% risk, over 18 years; nevertheless, eleven minors requested their inclusion in the program. A retrospective and descriptive study based on the analysis of the medical records belonging to these individuals was designed. Being aware of how challenging clinical settings of predictive genetic testing for minors are, this paper reviews their profile, the outcome of the carried out studies, as well as the reproductive option chosen by the gene positive consultands. The mean age at the time of testing was 16.2 years. Nine adolescents completed the protocol (three had positive test results) and two withdrew. They had a distinctive profile; all were females, pregnant, motivated by the risk assessment for their descendants, and interested in PND with termination of the gestation were the fetus a carrier. Nevertheless, once the result of the test is known, the gene positive consultands chose discordant reproductive options. Further research is necessary to assess the long-term psychological impact in both gene positive and gene negative participants, as well as in their parents and at-risk relatives.