Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Table 3

HBV incidence adjusted for the probability of detecting transient HBsAg marker (PWP) and residual risk (RR) for repeat donors.

HBV prevalence	Method (reference)	Probability of HBV infected^1	PWP	RR (95% CI)
High	True values	0.0097286	1.0000	1 : 636
	Standalone HBsAg [63]	0.0012664; (0.003286, 0.001808)	0.2600	1 : 1270; (1 : 890, 1 : 1883)
	Müller-Breitkreutz [64]	0.0047867; (0.00419, 0.005447)	0.5906	1 : 354; (1 : 311, 1 : 404)
	Modified standalone HBsAg [44]	0.0012664; (0.00085, 0.00181)	0.5506	1 : 1434; (1 : 1005, 1 : 2126)
	HBsAg yield^2 [65]	0.000416	0.2991, 0.3789	1 : 7092; (1 : 6345, 1 : 8037)
	HBsAg and anti-HBc yield [66]	0.0092818; (0.0081, 0.0106)	0.99	1 : 667; (1 : 95, 1 : 765)
Low	True values	0.0009438	1.0000	1 : 6555
	Standalone HBsAg [63]	0.0001217; (0.0000251, 0.000357)	0.19856	1 : 1632; (1 : 556, 1 : 7911)
	Müller-Breitkreutz [64]	0.000600; (0.0000124, 0.0001753)	0.5444	1 : 30615; (1 : 10479, 1 : 148136)
	Modified standalone HBsAg [44]	0.0001217; (0.0000251, 0.000357)	0.5444	1 : 15093; (1 : 5145, 1 : 73183)
	HBsAg yield^2 [65]	0.000400; (0.0000048, 0.0001445)	0.2731, 0.3460	1 : 8052; (1 : 7225, 1 : 9152)
	HBsAg and anti-HBc yield [66]	0.000893; (0.00056, 0.00135)	0.99	1 : 6929; (1 : 4577, 1 : 11057)

1Probability of HBV-infected donation (HBV incidence).
²Instead of 95% CI, a range between the extremes of the window period (30–38 days) is given.