Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Table 4

HBV residual risk (RR) estimates for the first-time donors.

Method	HBV prevalence	First-time donors			Repeat donors			IR (variation)^c	RR for the first-time donors (variation)^d
		𝑠^a	𝑛	(%)^b	𝑠^a	𝑛	(%)^b
HBsAg yield	High	100	51950	0.1925	20	48050	0.0416	4.62	1 : 1533; (1 : 888, 1 : 2843)
	Low	10	50000	0.0200	2	50000	0.0040	5.00	1 : 1610; (1 : 4000, 1 : 151280)
HBsAg and anti-HBc yield	High	130	51950	0.2500	30	48050	0.0624	4.01; (2.69, 5.96)	1 : 166; (1 : 112, 1 : 247)
	Low	13	50000	0.0260	3	50000	0.0060	4.33; (1.23, 15.20)	1 : 1599; (1 : 456, 1 : 5610)

^aNumber of HBV-seroconverting donors.
^bPercentage of HBV-seroconverting donors.
^cIC: Incidence ratio for the first-time to repeat donor; no variation was calculated for the yield method whereas 95% CI of the risk ratio was used for the HBsAg and anti-HBc yield method.
^dMultiplies of the plausible range for the yield method versus 95% CI of the risk ratio for the HBsAg and anti-HBc yield method.