The Epidermal Growth Factor Receptor Increases Cytokine Production and Cutaneous Inflammation in Response to Ultraviolet Irradiation
Figure 2
EGFR inhibition reduces TNF-α, KC, and IL-1α in keratinocytes following UV exposure. Subconfluent keratinocytes were treated with 1 μM AG1478 or the vehicle DMSO. Cells were exposed to 600 J/m2 UV and cell lysate (left panel) and media (right panel) were prepared at 16 h for cytokine analysis using Luminex technology. Data from at least two different experiments, with at least three dishes per group, are presented as mean ± standard error. *Mean is significantly different from the corresponding sham-irradiated control or **significantly different from the corresponding vehicle-treated group, using a Student’s -test, where .
