Research Article

Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

Figure 2

Histological study of pigment spread after dermabrasion + 5-FU ointment. (a) Day 15. Disrupted aspect of the epidermis, enlarged intercellular spaces, clustered melanocytes at the margin, (white arrow), and migrating melanocyte with a long dendrite from the margin (black arrow) (Dopa 400x). (b) Day 30. Thin epidermis with migrating melanocytes from the margin (white arrows) (HES + Dopa 100x).
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(a)
852497.fig.002b
(b)