Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study
Figure 3
Comparative aspect of melanocytes under electron microscope (linear Scale = 2 μm). Following dermabrasion alone: (a) on day 15, after complete healing, normal appearing melanocyte (M) and keratinocytes (K), enlarged intercellular space (ICS); (b) on day 30, normal aspect and cohesion of the epidermis of the margin (6.000). Following dermabrasion + 5-Fu: (c) on day 15, after complete healing, disrupted aspect of the epidermis, damaged keratinocytes (DK) surrounding active melanocyte (VM) with vacuolated cytoplasm, enlarged intercellular spaces (ICS); (d) on day 30, normal appearing keratinocytes (K), migrating melanocyte (VM) with vacuolated cytoplasm, and persistent enlargement of intercellular spaces (ICS) (×6.000).
