Rescue High-Frequency Oscillatory Ventilation for Congenital Diaphragmatic Hernia: What about Lung Histopathology and Necropsy Findings?

Table 4

Median ventilation settings, PaCO₂, OI, and arterial pH before (CMV) and after staring on HFOV.

CMV	HFOV
Frequency—70/min (30–75)	Amplitude—50 (27–90)
Inspiratory pressure—25 (22–30) cmH2O	Continuous distending pressure (CDP)—16 (12–21) cmH2O
Mean pressure—11 (7–15) cmH2O
FiO2-1	FiO2-1
PaCO2 median (min-max) 80 (70–110)	PaCO2 median (min-max) 45 (35–65), P = 0.001
OI median (min-max) 23 (6–30)	OI median (min-max) 24 (7–32), P = 0.785
pH median (min-max) 7.12 (7.0–7.25)	pH median (min-max) 7.25 (7.20–7.40), P = 0.02

CDP: continuous distending pressure; CMV: conventional mechanical ventilation; FiO₂: fraction of inspirited oxygen; HFOV: high-frequency oscillatory ventilation; OI: oxygenation index; PaCO₂: partial pressure of arterial carbon dioxide.