
Rituximab 375 mg/m^{2} intravenously in 250 mL normal saline  

Cycle 1  
10 mL/h (first 1 hour) → 50 mL/h (second 1 hour) → 100 mL/h (until end of treatment) 
Cycle 2–8  
Cohort 1  50 mL/h (constant infusion, until end of treatment) 
Cohort 2  100 mL/h (constant infusion, until end of treatment) 
Cohort 3  150 mL/h (constant infusion, until end of treatment) 
Cohort 4  200 mL/h (constant infusion, until end of treatment) 
Cohort 5  250 mL/h (constant infusion, until end of treatment) 
Cohort 6  300 mL/h (constant infusion, until end of treatment) 
