Research Article

Generation of Constitutive Active ERK Mutants as Tools for Cancer Research in Zebrafish

Table 5

Cluster 2 gene ontology.

PeptideName proteinFunctions

P53_12_24Cellular tumor antigen p53. Tumor suppressor p53. Phosphoprotein p53. Antigen NY-CO-13 Protein import into nucleus, negative regulation of transcription from RNA polymerase II promoter, transcription factor activity, embryonic development, somitogenesis, release of cytochrome c from mitochondria, T cell proliferation involved in immune response, B/T cell lineage commitment, DNA binding chromatin binding, DNA double-strand break repair, apoptotic process, DNA damage response, ER overload response, cell cycle arrest, Ras protein signal transduction, multicellular organismal development, gastrulation, negative regulation of neuroblast proliferation, central nervous system development, cell aging, blood coagulation, rRNA transcription, X-ray response, gamma radiation

KS6A1_374_386Ribosomal protein S6 kinase alpha-1.S6K-alpha 1. p90-RSK 1. pp90RSK1. p90S6K. RSK-1. MAPKAPK1A Toll-like receptor signaling pathway, cell cycle, synaptic transmission, axon guidance, negative regulation of apoptotic process, regulation of translation in response to stress, regulation of DNA-dependent transcription in response to stress, innate immune response, cell differentiation positive regulation of transcription from RNA polymerase II promoter, nerve growth factor receptor signaling pathway, stress-activated MAPK cascade

GSUB_61_73G-substrate. C7orf16.protein phosphatase 1. regulatory subunit 17 (PPP1R17)Central nervous system development

GPR6_349_361Sphingosine 1-phosphate receptor. G-protein coupled receptor 6 G-protein coupled receptor activity

ESR1_160_172Estrogen receptor (ER). Estradiol receptor (ER-alpha). Nuclear receptor subfamily 3 group A member 1Epithelial cell development, osteoblast development, sequence-specific DNA binding, transcription factor activity, steroid hormone receptor activity, DNA-dependent transcription initiation from RNA polymerase II promoter, beta-catenin binding, transcription factor binding, androgen metabolic process, chromatin remodeling complex, nitric-oxide synthase regulator, estrogen receptor signaling pathway, type 1 metabotropic glutamate receptor binding, response to estradiol stimulus, regulation of apoptotic

CA2D1_494_506Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor. CACNA2D1Voltage-gated calcium channel complex, sarcoplasmic reticulum, T-tubule

ANDR_785_797Androgen receptor. Dihydrotestosterone receptor. Nuclear receptor subfamily 3 group C member 4 In utero embryonic development, DNA binding, chromatin binding, transcription factor activity, androgen receptor activity, sex differentiation, beta-catenin binding, positive regulation of cell proliferation, male gonad development, prostate gland development, response to insulin stimulus, positive regulation of intracellular estrogen receptor signaling pathway, negative regulation of apoptotic process, positive regulation of MAPK cascade, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of integrin biosynthetic process, negative regulation of epithelial cell proliferation, positive regulation of NF-kappaB transcription factor activity, prostate gland development

ACM5_498_510
ACM5_494_506
Muscarinic acetylcholine receptor M5. cholinergic receptor. muscarinic 5ā€‰