The Human Frontal Lobes and Frontal Network Systems: An Evolutionary, Clinical, and Treatment Perspective

Table 11

Different classification systems and current status of antibodies implicated: autoimmune dementia may be idiopathic or secondary to cancer (paraneoplastic) [29].

Eponymous
Morvan syndrome
Syndromic
Progressive encephalomyelopathy with rigidity and myoclonus
Serologically
VGKC antibody associated encephalopathy
Pathologically
Nonvasculitic autoimmune meningoencephalitis
Antibodies
VGKC
NMDA receptor antibody
AMPA receptor
GABAB receptor
GAD 65
ANNA-1 (anti-Hu)
ANNA-2 (anti-Ri)
ANNA-3
AGNA (SOX-1)
PCA-2
CRMP-5 (anti-CV2)
Amphiphysin
Ma/Ta proteins
NMO-IgG

VGKC: voltage gated potassium channel, NMDA: N-methyl D-aspartate, AMPA: alpha-amino-3-hydroxy-5-methyl-isoxazolepropionic acid, GABA: gamma-aminobutyric acid, GAD: glutamic acid decarboxylase 65, ANNA, antineuronal nuclear antibody, AGNA: antiglial nuclear antibody, PCA: Purkinje cell cytoplasmic antibody, CRMP 5: collapsing response mediator protein 5, NMO: neuromyelitis optica IgG antibodies (modified from Mckeon et al.) [30].