Limb perfusion in diabetic versus nondiabetic mice by laser-Doppler perfusion imaging. (a) Femoral artery blood flow by laser-Doppler perfusion imaging in sRAGE-treated versus nontreated diabetic mice before surgery and on days 3, 7, and 14 after surgery. Representative images of the ischemic (left) and nonischemic (right) hindlimbs. (b) Laser-Doppler ischemic/nonischemic limb perfusion ratios.