- About this Journal ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2013 (2013), Article ID 910308, 10 pages
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells
1Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
2Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, P.O. Box 198, Gondar, Ethiopia
3Physiology Department, Medical Faculty, Jimma University, P.O. Box 378, Jimma, Ethiopia
4Department of Tropical Medicine, Medical Mission Institute, Salvatorstrasse 7, 97067 Würzburg, Germany
5Department of Veterinary Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany
6Department of Zoology, Faculty of Science, University of Alexandria, Maharram Bey, Alexandria 21511, Egypt
Received 29 May 2013; Accepted 13 August 2013
Academic Editors: S.-P. Scott and N. Sergeant
Copyright © 2013 Netsanet Worku et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. V. Barrett and M. P. Barrett, “Anti-sleeping sickness drugs and cancer chemotherapy,” Parasitology Today, vol. 16, no. 1, pp. 7–9, 2000.
- M. Kaur, E. Reed, O. Sartor, W. Dahut, and W. D. Figg, “Suramin's development: what did we learn?” Investigational New Drugs, vol. 20, no. 2, pp. 209–219, 2002.
- M. P. Barrett, D. W. Boykin, R. Brun, and R. R. Tidwell, “Human African trypanosomiasis: pharmacological re-engagement with a neglected disease,” British Journal of Pharmacology, vol. 152, no. 8, pp. 1155–1171, 2007.
- World Health Organization, “African trypanosomiasis (sleeping sickness),” World Health Organization Fact Sheet, 2006, http://www.who.int/mediacentre/factsheets/fs259/en/.
- P. Cattand, J. Jannin, and P. Lucas, “Sleeping sickness surveillance: an essential step towards elimination,” Tropical Medicine and International Health, vol. 6, no. 5, pp. 348–361, 2001.
- F. A. S. Kuzoe and C. J. Schofield, “Strategic review of traps and targets for tsetse and African trypanosomiasis control,” Special Programme for Research and Training in Tropical Diseases (TDR), UNICEF-UNDP-World Bank-WHO, 2004.
- WHO/TDR/SWG/01, “Drug development, preclinical and clinical studies and drug resistance,” Report of the Scientific Working Group Meeting on African Trypanosomiasis, 2001.
- N. N. Al-Hebshi and N. Skaug, “Khat (Catha edulis)—an updated review,” Addiction Biology, vol. 10, no. 4, pp. 299–307, 2005.
- A. R. Bilia, P. M. de Malgalhaes, M. C. Bergonzi, and F. F. Vincieri, “Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar,” Phytomedicine, vol. 13, no. 7, pp. 487–493, 2006.
- L. N. Misra, A. Ahmad, R. S. Thakur, and J. Jakupovic, “Bisnor-cadinanes from Artemisia annua and definitive 13C NMR assignments of β-arteether,” Phytochemistry, vol. 33, no. 6, pp. 1461–1464, 1993.
- I. Nakase, H. Lai, N. P. Singh, and T. Sasaki, “Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation,” International Journal of Pharmaceutics, vol. 354, no. 1-2, pp. 28–33, 2008.
- G.-Q. Zheng, “Cytotoxic terpenoids and flavonoids from Artemisia annua,” Planta Medica, vol. 60, no. 1, pp. 54–57, 1994.
- N. P. Singh and H. C. Lai, “Artemisinin induces apoptosis in human cancer cells,” Anticancer Research, vol. 24, no. 4, pp. 2277–2280, 2004.
- B. Mark and G. Lori, American Botanical Council, Herbclip, 2007.
- R. Sen, S. Bandyopadhyay, A. Dutta et al., “Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes,” Journal of Medical Microbiology, vol. 56, no. 9, pp. 1213–1218, 2007.
- S. R. Meshnick, T. W. Tsang, F. B. Lin et al., “Activated oxygen mediates the antimalarial activity of qinghaosu,” Progress in Clinical and Biological Research, vol. 313, pp. 95–104, 1989.
- V. Dhingra, K. Vishweshwar Rao, and M. Lakshmi Narasu, “Current status of artemisinin and its derivatives as antimalarial drugs,” Life Sciences, vol. 66, no. 4, pp. 279–300, 1999.
- D. Abebe and A. Ayehu, Medicinal Plants and Enigmatic Health Practices of Northern Ethiopia, Birhanena Selam Priniting Enterprise, Addis Ababa, Ethiopia, 1993.
- T. Mekonnen, K. Urga, and E. Engidawork, “Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 433–439, 2010.
- M. Wegiera, H. D. Smolarz, and A. Bogucka-Kocka, “Rumex L. species induce apoptosis in 1301, EOL-1 and H-9 cell lines,” Acta Poloniae Pharmaceutica, vol. 69, no. 3, pp. 487–499, 2012.
- A. Ouaissi and M. Ouaissi, “Molecular basis of Trypanosoma cruzi and Leishmania interaction with their host(s): exploitation of immune and defense mechanisms by the parasite leading to persistence and chronicity, features reminiscent of immune system evasion strategies in cancer diseases,” Archivum Immunologiae et Therapiae Experimentalis, vol. 53, no. 2, pp. 102–114, 2005.
- J. W. Chambers, M. L. Fowler, M. T. Morris, and J. C. Morris, “The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1,” Molecular and Biochemical Parasitology, vol. 158, no. 2, pp. 202–207, 2008.
- D. Steverding and K. M. Tyler, “Novel antitrypansomal agents,” Expert Opinion on Investigational Drugs, vol. 14, no. 8, pp. 939–955, 2005.
- A. H. Fairlamb, “Chemotherapy of human African trypanosomiasis: current and future prospects,” Trends in Parasitology, vol. 19, no. 11, pp. 488–494, 2003.
- A. Deterding, F. A. Dungey, K.-A. Thompson, and D. Steverding, “Anti-trypanosomal activities of DNA topoisomerase inhibitors,” Acta Tropica, vol. 93, no. 3, pp. 311–316, 2005.
- D. Steverding and X. Wang, “Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei,” Journal of Antimicrobial Chemotherapy, vol. 63, no. 6, pp. 1293–1295, 2009.
- D. Steverding and X. Wang, “Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib,” Parasites and Vectors, vol. 2, no. 1, article 29, 2009.
- M. Aboulaila, N. Yokoyama, and I. Igarashi, “Inhibitory effects of (-)-epigallocatechin-3-gallate from green tea on the growth of Babesia parasites,” Parasitology, vol. 137, no. 5, pp. 785–791, 2010.
- E. E. Balint, G. Falkay, and G. A. Balint, “Khat—a controversial plant,” Wiener Klinische Wochenschrift, vol. 121, no. 19-20, pp. 604–614, 2009.
- T. Bredholt, E. A. Dimba, H. R. Hagland et al., “Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines,” Molecular Cancer, vol. 8, article 101, 2009.
- P. Kalix, “Recent advances in khat research,” Alcohol and Alcoholism, vol. 19, no. 4, pp. 319–323, 1984.
- E. Dimba, B. T. Gjertsen, G. W. Francis, A. C. Johannessen, and O. K. Vintermyr, “Catha edulis (Khat) induces cell death by apoptosis in leukemia cell lines,” Annals of the New York Academy of Sciences, vol. 1010, pp. 384–388, 2003.
- V. Rosenkranz and M. Wink, “Alkaloids induce programmed cell death in bloodstream forms of Trypanosomes (Trypanosoma b. brucei),” Molecules, vol. 13, no. 10, pp. 2462–2473, 2008.
- N. N. Al-Hebshi, A. K. Al-Sharabi, H. M. Shuga-Aldin, M. Al-Haroni, and I. Ghandour, “Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients,” Journal of Ethnopharmacology, vol. 132, no. 3, pp. 564–569, 2010.
- D. Sinclair, B. Zani, S. Donegan, P. Olliaro, and P. Garner, “Artemisinin-based combination therapy for treating uncomplicated malaria,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD007483, 2009.
- J. Wiesner, R. Ortmann, H. Jomaa, and M. Schlitzer, “New antimalarial drugs,” Angewandte Chemie—International Edition, vol. 42, no. 43, pp. 5274–5293, 2003.
- D. Steverding, “The transferrin receptor of Trypanosoma brucei,” Parasitology International, vol. 48, no. 3, pp. 191–198, 2000.
- Y. V. Mishina, S. Krishna, R. K. Haynes, and J. C. Meade, “Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth,” Antimicrobial Agents and Chemotherapy, vol. 51, no. 5, pp. 1852–1854, 2007.
- Z. Maksimović, N. Kovacević, B. Lakusić, and T. Cebović, “Antioxidant activity of yellow dock (Rumex crispus L., Polygonaceae) fruit extract,” Phytotherapy Research, vol. 25, no. 1, pp. 101–105, 2011.
- H. Zhang, Z. Guo, N. Wu et al., “Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines,” Molecules, vol. 17, no. 1, pp. 843–850, 2012.