Development and Validation of a Stability Indicating RP-UPLC Method for Analysis of Imipramine Hydrochloride in Pharmaceuticals

Table 8

Summary of forced degradation results.

Degradation condition	Time	Drug decomposed (%)*	% of drug remaining after degradation*	Remarks
HCl 1 M at 80°C	6 h	19.98	80.02	Degradation
NaOH 1 M at 80°C	6 h	10.55	89.45	Degradation
Water hydrolysis (80°C)	6 h	0.98	99.02	No degradation
Oxidation by H2O2 (5%), 80°C	6 h	13.13	86.9	Degradation
Thermal solid, 80°C	24 h	1.09	98.91	Negligible degradation
UV at 220 nm	Kept in a photostability chamber for 10 days	1.42	98.58	Negligible degradation

 *Mean value of three replicates.