Development and Validation of a Stability Indicating RP-UPLC Method for Analysis of Imipramine Hydrochloride in Pharmaceuticals

Table 9

Results of determination of IMH in tablet and statistical comparison with the reference method.

Formulation brand name	Nominal amount, mg/tab	% IMH found* ± SD
		Reference method	Proposed method	t-value	F-value
Imipramine^a	25 mg	99.38 ± 0.30	99.95 ± 0.15	2.007	4.064
Depranil^b	25 mg	99.55 ± 0.22	100.04 ± 0.13	2.174	2.723

Marketed by ^aSun and ^bLa Pharma.
*Mean value of five determinations.
Tabulated t-value at 95% confidence level is 2.78; tabulated F-value at 95% confidence level is 6.39.