Review Article

Skin Photoaging and the Role of Antioxidants in Its Prevention

Table 2

Exogenous antioxidant’s mixtures with photoprotective or damage protective effects.

Antioxidant mixtures Outcome of the studyStudy

Oral vitamin E and beta-carotene supplementationUltraviolet radiation-induced oxidative stress in human skinMcArdle et al., 2004 [85]
Carotenoids and tocopherolsScavenging reactive oxygen species generated during photooxidative stressStahl et al., 2000 [86]
Beta-carotene, lutein, and lycopeneUV irradiation induced intensity of erythema was diminishedAlbanes et al., 1996 [87]
Tomato extract and a drink containing solubilized Lyc-o-Mato Reduction in erythema formation following UV irradiationAust et al., 2005 [88]
Quercetin, hesperetin and naringeninProtective agents in certain skin diseases caused, initiated, or exacerbated by sunlight irradiationBonina et al., 1996 [89]
-Tocopherol and ascorbateMEDs increased markedly after intake of the combination of -tocopherol and ascorbateFuchs and Kern, 1998 [45]
Combination of vitamins C and E Mean MEDs increased in group receiving vitamins compared with baseline Eberlein-Konig et al., 1998 [90]
Vitamin C, vitamin E, lycopene, beta-carotene, the rosemary polyphenol, and carnosic acid Vitamin C, vitamin E, and carnosic acid showed photoprotective potential human dermal fibroblasts exposed to ultraviolet-A (UVA) Offord et al., 2002 [91]
Lycopene, beta-carotene, alpha-tocopherol, and seleniumMany parameters of the epidermal defense against UV-induced damage were significantly improved C sarini et al., 2003 [92]
-Carotene, lycopene, tocopherol, and ascorbic acidSignificant increase of melanin concentrations in skin was foundPostaire et al., 1997 [93]
Carotenoids (beta-carotene and lycopene), vitamins C and E, selenium, and proanthocyanidinsA selective protection of the skin against irradiation was confirmedGreul et al., 2002 [94]