Effect of Polyherbal Mixtures on the Treatment of Diabetes
Table 3
Antihyperglycemic activity of mixtures on STZ-induced diabetic rat.
Group ()
Dose (mg/kg)
Blood glucose level (mg/dL)
0 h
2 h
4 h
8 h
12 h
21 days
value
Normal control
2 mL/kg
92.46 ± 3.59
90.66 ± 2.57
92.75 ± 4.53
89.66 ± 2.72
91.67 ± 4.66
90.68 ± 3.22
8.05
Diabetic control
2 mL/kg
234.46 ± 3.59
240.66 ± 2.57
237.54 ± 2.53
241.54 ± 2.66
259.21 ± 3.44
255.3 ± 2.11
0.55
Glibenclamide
10
241.33 ± 4.26**
201.83 ± 3.65**
162.56 ± 2.33**
125.33 ± 2.32**
84.66 ± 3.11**
81.33 ± 2.12**
130.58
Mixture 1
400
244.60 ± 2.6**
188.8 ± 3.33**
168.33 ± 2.33**
111.83 ± 2.33**
74.33 ± 3.33**
78.43 ± 2.11**
127.32
Mixture 2
400
265.83 ± 2.33**
196.8 ± 3.33**
155.33 ± 2.33**
107.33 ± 2.33**
77.16 ± 2.67**
78.11 ± 2.11**
121.55
Mixture 3
400
266.32 ± 2.33*
222.6 ± 2.67*
169.33 ± 2.33*
127.16 ± 2.67*
94.66 ± 2.67*
92.12 ± 3.12*
119.32
Mixture 4
400
278.00 ± 2.55**
151.00 ± 2.33**
135.83 ± 2.33**
128.83 ± 2.33**
78.33 ± 3.33**
81.21 ± 4.11**
100.43
Mixture 5
400
237.16 ± 2.67*
162.6 ± 3.67*
138.66 ± 2.67*
108.66 ± 2.67*
84.33 ± 3.33*
81.76 ± 1.21*
118.43
Results expressed as mean ± SD (). Treatment was done for 21 days. The data were statistically analysed by one-way ANOVA, followed by Dunnett’s -test. , . values less than 0.01 were considered more significant.
