Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

Table 3

Effect of LTG on physical growth of male and female offspring.

Group	Treatment	Day of pinna detachment		Day of incisor eruption		Day of eye opening		Day of testes; descent	Day of vaginal; opening
		Male	Female	Male	Female	Male	Female
I	Control	4.33±0.33	4.67±0.33	7.33±0.33	7.33±0.33	16.67±0.33	16.00±0.33	6.33±0.33	32.67±0.33
II	LTG; (11.5 mg/kg, p.o)	5.33±0.33	5.33±0.33	9.33±0.33^∗	9.00±0.57	15.66±0.66	15.00±0.67	6.23±1.67	40.57±0.33^∗∗
III	LTG; (23 mg/kg, p.o)	5.30±0.29	5.66±0.33	9.50±0.64^∗	9.33±0.33^∗	15.33±0.33	14.33±0.33	9.00±0.00	54.00±1.00^∗∗

𝑛=8/group (4/sex). Values are expressed in mean ± SEM. Significance with Tukey’s test following one way ANOVA is indicated as ^∗𝑃≤0.05 and ^∗∗𝑃≤0.01 versus control group.